Acute Liver Failure is the rapid development of dysfunction or failure of theÂ Liver [hepatocellular dysfunction].
Encephalopathy (a mental status changes) is one of the many complications of this condition.
Jaundice and impaired protein syntheses are other complications.
Usually occurs when a history of liver disease, Hepatitis, Alcohol, or other cause is present.
However, in some cases there is an absence of a prior history of liver disease.
TheÂ Liver is a central mode of control for many enzymes and detoxification of the blood
-Â Severe damage to liver cells
-Â Decrease coagulation
-Â Increase platelet function
-Â Renal failure is seen in 40-50% of the time
*** Individuals can present as hepatocellular injury, hepatic encephalopathy, infection, GI bleed, or multiple organ failure
-Â Reye Syndrome
-Â Wilsons Disease
-Â and others
Classification [from 1993]:
Hyperacute as within 1 week
Acute as 8-28 days
Subacute as 4-12 weeks
-Â Physical Exam
-Â Lab work
-Â CT of liver/abdoman
Â Â -Â Hospital AdmissionÂ is oftenÂ necessary
-Â Nutrition improvement
Â Â -Â Liver transplant