Acute Lymphoblastic Leukemia (ALL) is one of the 4 main types of Leukemia
The other major types of Leukemia are:
This disease can progress swiftly [Acute]
It is a cancer of the white blood cells (WBC) and an increase in lymphoblasts are seen.
Within the Bone Marrow a production of WBC is seen that are immature.
The concerning factor is when the other necessary blood cells become out-produced by the immature WBC.
Seen most often between ages 4-12 then again much later in life.
85% of children respond well to treatment while 50% of adults have good outcomes.
Without treatment – the time period from onset to death may be a few weeks to months.
Cancer may move to different areas of the body [metastasize].
- Weight loss
- Bone pain
- Joint pain
- Loss of appetite
- Swelling in legs
- Enlargement of lymph nodes
- Enlargement of Spleen
- Enlargement of Liver
- The cause is not known
- Genetic [theory]
- Change or damage to DNA
- Nuclear radiation exposure
- Other chemical exposure
- Blood work is essential to diagnosis
- White blood count will be quite elevated
- Blast cells are often seen
- Biopsy of bone marrow is definitive
- Spinal tap may detect involvement of Brain
*** The earlier detected is better
To Induce Remission [rapidly kill tumor cells]
. Dexamethasone (children)
. Daunorubicin (adults)
Intensification [causes tumor to decrease in size]
Steroids as well
- Used for painful areas
- Used prior to bone marrow transplant
Bone Marrow Transplant