Antigen Presentation allow for and is an integral part in the Immune System and the protection of the body to foreign invaders.
Is a specific part of the adaptive immune system.
Specific cells such as Dendritic cells and Macrophages are the key components and they proceed to entrap and capture antigens
It is essential in this process for the cells to determine which are “self” cells and which are “non-self“.
“Self” is the host’s cells and specific antigen will identify them as belonging to the host.
Bacteria, viruses, and other particles will have different and separate antigens that will be identified and determined as “non-self“.
Environmental antigens, antigens from within the body (cancer, viruses)
– These antigens are inhaled, ingested, or injected
– Engulfed by dendritic cells, macrophages
– These will then “present” the foreign object to specific cells
– B cells will produce antibodies against these antigens
– Phagocytosis then occurs
– These antigens are created with a cell
– Virus and Cancer are good examples
– Often fragments are found
– Recognition occurs by cellular structures occur
– Cytotoxic T cells are presented with the cellular debris or particles.
Several pathways are identified depending on the “Class histocompatibility molecule” either I or II