Bisphosphonates are a class of medications that can prevent loss of bone mass.
Bone is replaced on a cellular level quite often.
Certain cells help in this process such as: osteoblasts and osteoclasts.
Uses of this medication include:
Method of Action
– Slows down the breakdown of bone
Two classifications of medicine
1.) N-containing bisphosphonates
2.) Non-N-containing bisphosphonates
– Bind to enzymes necessary for the breakdown of bone and cause a block of the activity of that enzyme.
1.) Sodium Alendronate [Fosamax]
– Given 10mg every day or
– Given 70mg once a week
2.) Risedronate [Actonel]
– Given 5mg every day or
– Given 35mg once a week
3.) Ibandronate [Boniva
– Given once a month
4.) Zoledronic Acid [Zoledronate, Zometa]
– Given different doses depending on the diagnosis
– Used in patients with cancers such as multiple myeloma and prostate cancer to prevent cancer
5.) Pamidronate [Aredia]
– Are metabolized in cells and transformed into compounds that affect bone destruction
1.) Etidronate [Didronel]
2.) Tiludronic [Skelid]
– Stomach pain
– Irritation of esophagus
– Necrosis of jaw
– Joint pain
– Muscle pain