Meglitinide is a group of medications that are used for the treatment of Diabetes Mellitus Type 2. These can also be referred to as “glinides” and work by triggering production of insulin.

This medication can stimulate beta cells to be more productive. This class of medications is meant to lower blood sugar after meals, and is particularly helpful for those with flexible schedules of eating when consistent meals are not always possible.

Meglitinides have been approved by the U.S. Food and Drug Administration for type 2 diabetes since 1997. The first drug in this class, Repaglinide (Prandin) was approved in 1997 and a second, Nateglinide (Starlix) was approved in 2000.


–  Similar action as Sulfonylureas
–  Increases the amount of insulin in the blood stream
–  Decreases blood sugar levels


   –   Repaglinide  [Prandin]
   –   Nateglinide  [Starlix]


1.) Diabetes Mellitus Type 2

–  Take prior to eating [0-30 minutes]

Side Effects:

–   Weight gain
–   Nausea
–   Diarrhea
–   Hypoglycemia
–   Abdominal discomfort
–   others