– Also called 6-Mercaptopurine and 6-MP

– Is an class of drug that is used as a immunosupprressant

Uses:

-     Non-Hodgkin’s lymphoma
-     Leukemia
-     Psoriatic Arthritis
-     Crohn’s Disease
-     Ulcerative Colitis
-     Polycythemia vera
-     others

Method of Action:

-      Is converted to ribonucleotide
-      Inhibits Purine synthesis
-      Alters DNA and RNA production

Side Effects:

-     Nausea
-     Vomiting
-     Diarrhea
-     Rash
-     Abdominal pressure
-     Abdominal pain
-     Bloating
-     Hair loss
-     Color change of skin, eyes
-     Darkening of urine

***  Can cause decrease in production of white and red blood cells

**  Weekly blood work is often recommended

*  Allopurinal should be reduced or stopped due to drug interaction

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