Also referred to as HMG-CoA reductase inhibitors

Is a specific class of medications that acts to lower cholesterol.

Uses: Heart failure Heart Failure, Elevated Cholesterol, arteriosclerosis, Atherosclerosis.

Method of Action:
-   lowers cholesterol production
-   inhibits enzyme HMG-CoA reductase
-   this enzyme is produced in the liver and causes production of cholesterol

Types:

.         Atorvastatin   [Lipitor]
.         Fluvastatin   [Lescol]
.         Lovastatin   [Mevacor, Altocor]
.         Mevastatin
.         Pitavastatin   [Livalo]
.         Pravastatin   [Pracachol]
.         Rosuvastatin   [Crestor]
.         Simvastatin   [Zocor]

Combinations

.         Atorvastatin + Amlodipine   [Caduet]
.         Lovastatin + Niacin   [Advicor]
.         Simvastatin + Ezetimibe   [Vytorin]
.         Simvastatin + Niacin   [Somcor]

Adverse Effects
-      Elevated liver enzymes [LFT's]
-      Skeletal muscle damage or pain
-      Muscle cramps
-      GI upset

Grapefruit or Grapefruit juice can inhibit metabolism of statins – which increases the level of statins