Acute Lymphoblastic Leukemia (ALL) is one of the 4 main types of Leukemia
The other major types of Leukemia are:
This disease can progress swiftly [Acute]
Acute Lymphoblastic Leukemia (ALL) is a cancer of the white blood cells (WBC) and an increase in lymphoblasts are seen.
Within the Bone Marrow a production of WBC is seen that are immature.
The concerning factor is when the other necessary blood cells become out-produced by the immature WBC.
Seen most often between ages 4-12 then again much later in life.
85% of children respond well to treatment while 50% of adults have good outcomes.
Without treatment – the time period from onset to death may be a few weeks to months.
Cancer may move to different areas of the body [metastasize].
– Weight loss
– Bone pain
– Joint pain
– Loss of appetite
– Swelling in legs
– Enlargement of lymph nodes
– Enlargement of Spleen
– Enlargement of Liver
– The cause is not known
– Genetic [theory]
– Change or damage to DNA
– Nuclear radiation exposure
– Other chemical exposure
– Blood work is essential to diagnosis
– White blood count will be quite elevated
– Blast cells are often seen
– Biopsy of bone marrow is definitive
– Spinal tap may detect involvement of Brain
*** The earlier detected is better
To Induce Remission [rapidly kill tumor cells]
. Dexamethasone (children)
. Daunorubicin (adults)
Intensification [causes tumor to decrease in size]
Steroids as well
- Used for painful areas
- Used prior to bone marrow transplant
Bone Marrow Transplant