AML 1Acute Myeloid Leukemia (AML) is one of the 4 main types of Leukemia.

It can also be referred to as Acute Myelogenous Leukemia.

The other major types of Leukemia are:

1.)  Acute Lymphoblastic Leukemia (ALL)

2.)  Chronic Lymphocytic Leukemia (CLL)

3.)  Chronic Myelogenous Leukemia (CML)


This type of Leukemia is a cancer of the blood cells, specifically the myeloid cells.

Affects the white blood cells (WBC) within the Bone Marrow

This causes problems with the production of the normal blood cells.

Progression is quite rapid from onset to severe symptoms.

Very often affect adults and rarely in younger ages

A small amount of those who are treated actually become cured


  • Fatigue
  • Weakness
  • Fevers
  • Weight loss
  • Increased risk of infection
  • Bone pain
  • Joint pain
  • Bruising
  • Skin Inflammation
  • Loss of appetite
  • Swelling in legs
  • Shortness of breath
  • Enlargement of Spleen – usually less then ALL
  • Enlargement of Liver
  • others


Potential Causes

  • Specific cause is unknown
  • Chemical exposure
  • Genetics




M0  –  Minimally differentiated – acute myeloblastic leukemia
  –  No maturation – acute myeloblastic leukemia
M2  –  + Granulocytic maturation – acute myeloblatic leukemia
M3  –  Acute promyelocytic leukemia
  –  Acute myelomonoctic leukemia

M4eo  –  Bone marrow eosinophilia

M5 –  Acyte monoblastic leukemia or acute monocytic leukemia
–  Acute erythroid leukemia
M7  –  Acute megakaryoblastic leukemia



Blood work is essential to diagnosis

Bone marrow biopsy is essential




Induction: Attempt for complete remission

Cytarabine – used for 7 days
Daunorubicin – used for 3 days
. Idarubicin

All-trans-retinoic-acid  (ATRA)  –  typically used for M3 – acute promyelocytic leukemia

Consolidation: To prevent relapse and the non-detectable disease

Bone marrow transplant is often required

Chemotherapy is often required

AML that relapses

Bone Marrow transplant

gemtuzumab ozogamicin (Mylotarg)

arsenic trioxide – typically used for M3 – acute promyelocytic leukemia

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