Typically young women but can be seen in either sex and at any age. [Almost 70% of the time]

Can be a very quick initial onset.

Can progress to cirrhosis

In essence, the patient’s body is attacking its own liver for some reason.

Is seen in about 2 per every 100,000 individuals

Some cause agents are Hepatitis A, Epstein-Barr infection, measles, and drug or toxin agents.

Symptoms:
- Multiple spider nevi
- Striae
- Acne
- Hirsutism
- Enlarged liver
- Increased liver enzymes

Types:

Type I – SMA and/or ANA
Type II – Anti-LKMI – typically children 2-14 years of age
Type III – Anti SLA/LP

Treatment:
   -  Prednisone with or without Azathioprine – 80% response rate
   -  Mercaptopurine instead of Azathioprine in some cases
   -  If failure – cyclosporine, tacrolimus, or methotrexate
   -  Liver transplant may be required if treatment failure

Reoccurrences can occur in 40% of transplanted livers