Autoimmune Hepatitis is when the patient’s Immune System is attacking its own Liver causing potentially serious affects.

It is seen in about 2 per every 100,000 individuals

Some cause agents are: Hepatitis A, Epstein-Barr infection, measles, and drug or toxin agents.

Typically seen young women but can be seen in either sex and at any age. [Almost 70% of the time]

Can be a very quick initial onset.

Can progress to Cirrhosis or other response of the Inflammation process in the liver.

 

Symptoms:

  • Multiple spider nevi
  • Striae
  • Acne
  • Hirsutism
  • Enlarged liver
  • Increased liver enzymes

Types:

Type I – SMA and/or ANA
Type II – Anti-LKMI – typically children 2-14 years of age
Type III – Anti SLA/LP

 

Treatment:

  • Prednisone with or without Azathioprine – 80% response rate
  • Mercaptopurine instead of Azathioprine in some cases

If failure other medication options include

  • Cclosporine
  • Tacrolimus
  • Methotrexate

Liver transplant may be required if treatment failure

Reoccurrences can occur in 40% of transplanted livers

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