Bisphosphonates are a class of medications that can prevent loss of bone mass.

Bone is replaced on a cellular level quite often.

Certain cells help in this process such as: osteoblasts and osteoclasts.

 

Uses of this medication include:

 

Method of Action

  • Slows down the breakdown of bone

Two classifications of medicine

1.)  N-containing bisphosphonates

2.)  Non N-containing bisphosphonates

 

N-containing bisphosphonates

  • Bind to enzymes necessary for breakdown of bone and cause a block of that enzymes activity

.   Sodium Alendronate  [Fosamax]

  • Given 10mg every day or
  • Given 70mg once a week

.   Risedronate   [Actonel]

  • Given 5mg every day or
  • Given 35mg once a week

.   Ibandronate  [Boniva

  • Given once a mont

.   Zoledronic Acid  [Zoledronate, Zometa]

  • Given different doses depending on diagnosis
  • Used in patients with cancers such as multiple myeloma and prostate cancer to prevent cancer

.   Pamidronate   [Aredia]

.   Neridronate

.   Olpadronate

Non N-containing bisphosphonates

  • Are metabolised in cells and transformed into compounds that affect bone destruction

.   Etidronate  [Didronel]

.   Tiludronic  [Skelid]

.   Clodronate


Side Effects

  • Stomach pain
  • Nausea
  • Fatigue
  • Irritation of esophagus
  • Necrosis of jaw
  • Joint pain
  • Muscle pain
  • others
VN:F [1.9.22_1171]
Rating: 10.0/10 (1 vote cast)
VN:F [1.9.22_1171]
Rating: 0 (from 0 votes)
Bisphosphonates, 10.0 out of 10 based on 1 rating