This is not specifically a disease itself. It is rather a symptom or result of other diseases.
Cholestasis is an impairment of bile flow from the liver to the intestines
It can also be as a result of decreased production. Bile is formed in the liver
Stoppage can be catagorized as obstructive or metabolic
Obstructive can be as a result of a gallstone or a malignancy
Metabolic occurs due to an adverse effect of a medicaiton or a genetic causation.
Increased conjugated bilirubin
Mild increase in liver enzymes can be seen
Symptoms
- Hypercholemia [increased serum bile salt concentration]
- Pruritus [Itching]
- Jaundice
- Dark urine
- Hyperlipidemia
- Xanthomas
- Failure to thrive
Ultrasound and CT may be benifical
Biliary nuclear medicine study [HIDA]
Liver biopsy
Treatments
- Ursodeoxycholic acid
- Cholestyramine
- Phenobarbital
- Phytonadione (Vitamin K)
- Alpha tocopherol (Vitamin E)
- Vitamin A
- Ergocalciferol (Vitamin D)
- Antibiotics
- Surgery
- ERC
- Percutaneous transhepatic Cholangiography
- Removal of Gallbladder if appropriate
