Cirrhosis is a general condition that is the end result of liver injury and is often seen as chronic. It can lead to nodule formation and fibrosis of the Liver.

This can be a potentially serious medical condition that is generally unable to reverse.

There are several different causes that lead can to Cirrhosis. It is one of the top leading causes of death in the US about 1-2% of all deaths.

Cirrhosis can be divided into micronodular, macronodular, and mixed forms.

Causes the liver to loose its function such as:  metabolism of nutrients, bile production, and detoxification of blood along with other functions.

3 Main Clinical Features:

1.)  Hepatic cell dysfunction

2.)  Portosystemic shunting

3.)  Portal hypertension

Causes of Cirrhosis:

–  Alcoholic liver disease
–  Hepatitis C
–  Hepatitis B
–  Autoimmune Hepatitis
–  Primary and Secondary Bilary Cirrhosis
–  Primary Sclerosing Cholangitis
–  Alpha 1-Antitypsin Deficiency
–  Wilson’s Disease
–  Hemochromatosis
–  Drug induced liver disease
–  Many others

Some of the Most Common Symptoms of Cirrhosis:

–  Weakness
–  Fatigue
–  Weight loss
–  Nausea
–  Abdominal pain
–  Enlarged liver (70%)
–  Enlarged spleen fever
–  Acities
–  and others.

*** Varices are common finding with portal hypertension

How to Diagnosis Cirrhosis

1.) Doppler studies

2.) CT

3.) MRI

4.) Blood work

5.) Liver biopsy may be appropriate.

Treatment of Cirrhosis:

Treatment largely depends on the underlining cause. Treatment may help slow the progression.

–  Stop consuming alcohol

–  Diet change

–  Loss of weight

–  Diuretic: Spironolactone

–  Paracentesis

–  Transjugular intrahepatic portosystemic shunt (TIPS) for variceal bleeding that has no improvement with tradition means (endoscopic band ligation or sclerotherapy)

–  Antibiotics when necessary

–  Liver Transplant

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