“Lewy bodies” are the typical findings in this form of Dementia. They are are found as proteins (alpha-synuclein) in neurons of the brain – often detected on autopsy.
Affected neurons in the brain are “cholinergic neurons” and “dopaminergic neurons“.
Cholinergic neurons are affected in Alzheimer’s.
Dopaminergic neurons are affected in Parkinson’s.
A large sensitivity to medications related to neurolepic and antimetic medications.
Often symptoms start with Dementia with Lewy Bodies, when the patient notices that their body won’t respond as well as it used to. This will often continue to worsen over time. Approximately a year later, there is a change in memory and problems with critical thinking. Hallucinations can soon follow thereafter.
Some medications can worsen symptoms:
– Loss of attention
– Memory changes
– Vision changes
– Gait shuffling
– Blank facial expression
– Movements become more rigid
– Not well understood
– Genetics may be associated
There is no cure for this disease – but management is important
– Cabidopa + Levodopa (Sinemet)
– Donepezil (Aricept)
– Rivastigmine (Exelon)
– Galantamine (Reminyl)
– Botulinum toxin
– Over time the need for additional supervision is necessary
– Whether it is family members or a nursing homes
– Individuals will have good and bad days
– Maintain schedule
– Changes may cause relapses or worsening symptoms for that day or period