Thiazide
· Hydrochlorothiazide
· Metolazone
· Chlorthilidone
- Block sodium respoorption in cortical diluting segment – at terminal point of loop of Henle.
- Become ineffective when GFR goes below 30-40 mL/min
Loop Diuretics
· Furosemide
· Bumetanide
· Torsemide
- Inhibit chloride reabsorption in ascending limb of the loop of Henle
Potassium-Sparing agents
· Spironolactone
· Triamterene
· Eplerenone
· Amiloride
- Can be used in combo with Loop diuretics and Thiazides
- Triameterene and Amiloride work in distual tubule to limitpotassium secretion
- Spironolactone inhibits aldosterone – which is often elevated in CHF
- Eplerenone is used for post MI cases
