Gluconeogenesis is a metabolic pathway for the production of glucose from non-carbohydrate such as Protein, glycerol, amino acid, lactate and a few others.

This process occurs during periods of starvation, fasting, low-carb diets, and/or intense exercise.

This is one of two forms or systems of maintaining proper blood levels of glucose.

The other form breaks down glycogen in the pathway called glycogenolysis.

Once glucose is formed or when it is used, than it goes through its own transformation.

Glucose is broken down into pyruvate and is referred to as Glycolysis.

Can be a pathway in the following animals and plants:

  • Animals
  • Plants
  • Fungi
  • other microorganisms

Typically occurs in the Liver of animals.

Can also occur, to a lesser extent, in the Kidneys.

Gluconeogenesis occurs during periods of exercise, starvation, and/or fasting.

Lactic Acid is a strong example during exercise where the production of glucose is necessary.

During the overall process – several reactions occur that begin on a cellular level.

Typically this process begins in the mitochondria or cytoplasm

Medication for Diabetes MellitusMetformin– targets the process of gluconeogenesis to stop
glucose formation.


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