membrane attack

Membrane Attack Complex forms on the surface of a foreign or pathogenic cell.

This is a direct result of the cascade of the Complement System and is an important aspect of the immune system

Composed of several proteins from the complement system:

  • C5b
  • C6
  • C7
  • C8
  • C9

Forms a ring structure that attaches to the foreign cell.

Causes an opening or “punches a hole” into the outer cellular structure.

This pore causes a release of cellular components such as water, ions and small molecules from the foreign invaders

The result is lysis or death of the cell.

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