Mercaptopurine is also called 6-Mercaptopurine and 6-MP. It is a class of drugs/medications that are used as a immunosupprressants.  It is used for many different conditions from cancer to problems with the stomach.

It was approved for medical use in 1953 and is considered an “Essential Medication.” It is known as a necessary medication that is safe.

Typical Uses:

–  Non-Hodgkin’s lymphoma
–  Leukemia
–  Psoriatic Arthritis
–  Crohn’s Disease
–  Ulcerative Colitis
–  Polycythemia vera
–  others

Method of Action:

–  Is converted to ribonucleotide
–  Inhibits Purine synthesis
–  Alters DNA and RNA production

Side Effects:

–  Nausea
–  Vomiting
–  Diarrhea
–  Rash
–  Abdominal pressure
–  Abdominal pain
–  Bloating
–  Hair loss
–  Color change of skin, eyes
–  Darkening of urine

Additional Information

1.) This medications can cause decrease in production of white and red blood cells.

2.)  Weekly blood work is often recommended.

3.)  Allopurinal should be reduced or stopped due to drug interaction

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