Methotrexate is a class or type of medication that is referred to as “antimetabolite” and “anti-folate drug“.

Also seen as MTX and was called Amethopterin

Inhibits the production of Folic Acid.


  • Initially used as part of chemotherapy for cancer
  • Leukemia [acute lymphoblastic]
  • Other cancers
  • Early miscarriages
  • Ectopic Pregnancies
  • When added with misoprostol can terminate early pregnancies
  • Rheumatoid Arthritis
  • Psoriatic Arthritis
  • Psoriasis
  • Scleroderma
  • Ankylosing Spondyltis
  • Crohn’s Disease
  • Behcet’s disease
  • others
Method of Action:
  • Inhibits an enzyme that produce Tetrahydrofolic acid
  • This is intern needed for DNA production
  • Also required in Purine synthesis
  • Should have greater effectiveness on cells that rapidly divide

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Hair loss
  • Headache
  • Rash
  • Abdominal pain
  • Abdominal pressure
  • Bloating
  • Anemia
  • Decreased white blood cells
  • many others

**** – Higher doses for cancer may have additional side effects along with those mentioned above

*** – Small amount of individuals may develop hepatitis

  • Adverse effects are potential when also taking penicillin

When not to take

  • Not to be taken during pregnancy
  • Do not take if risk of becoming pregnant
  • Do not take if Lactating
  • Do not take If male and trying to get partner pregnant
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