Neuoleptic Malignant Syndrome – also known as NMS is a disorder that affects the neurological system and it can be life threatening.
Most often seen as an adverse reaction to medications – neuroleptic or antipsychotic drugs.
Dopaminergic receptors in the brain are believed to be blocked.
Result is a change in Skeletal Muscle causing an increased in heat generation along with difficulty with regulation of temperature.
Increased dosing of medication increases risk on NMS.
Occurs in 0.2% of those taking the above mentioned medications.
- Muscle rigidity – *** usually one of the first symptoms
- Fever – *** usually one of the first symptoms
- Change in blood pressure
- Mental status changes
- Tremors of muscle
- Visual changes
F – Fever
E – Encephalopathy
V – Vitals unstable
E – Elevated Enzymes (CPK elevation)
R – Rigidity of muscles
- This is an emergent medical situation
- Death is possible without treatment
- Medication must be stopped initially
- Hospital visit
- Treat for fever
- – Ice packs
- – Placement in groin, under arms, and chest region
- Possible need for ventilation
. Dantrolene sodium
*** – in some cases when the drug causing this condition is restarted – a recurrence of symptoms may occur – but for the most part it does not.