Plavix is a medication that helps control or even prevent blood clots.

It is classified as a Thienopyridine Class Antiplatelet Agent.

It is also known as Clopidogrel

There are several uses for this medications as well as side effects and drug interactions.


Method of Action:

This medication inhibits a receptor (P2Y12) on Adenosine Diphosphate [ADP] chemoreceptor.

This receptor can be found on Platelet cell membranes.

This medication permentantly (irreversibly) inhibits the receptor.

This prevents platelets from aggregating.

Begins to occur two hours after a single dose.



1.)  Prevention of some ischemic events

2.)  STEMI or ST elevated heart attacks

3.)  Prevention of blood clots

4.)  Prevention of clots after intracoronary stents

5.)  Coronary Artery Disease

6.)  Peripheral Vascular Disease

7.)  Cerebrovascular Disease  (Strokes)



Marketed as Clopidogrel Bisulfate

Often seen as 75mg oral tablets

Usually taken Once a day.

Can be taken with or without food and should be taken the same time each day.


Side Effects

  • Neutropenia  (Low white blood cells)
  • Thrombotic Thrombocytopenic Purpura  (TTP)
  • Thrombocytopenia  (Decreased amount of platelets)
  • Excessive bleeding  (Hemorrhage)
  • Stomach upset
  • Stomach or Gastric ulcers
  • Gastritis
  • Diarrhea
  • Rash
  • Increase frequency of cough or shortness of breath
  • Chest discomfort
  • Edema
  • Others

Possible Drug Interactions:

  • Aanistreplase (Eminase)
  • Ardeparin (Normiflo)
  • Dalteparin (Fragmin)
  • Danaparoid (Orgaran)
  • Dipyridamole (Persantine)
  • Enoxaparin (Lovenox)
  • Heparin
  • Fluvastatin (Lescol)
  • Proton pump inhibitors  (PPI)  (except possibly pantoprazole)
  • Phenytoin (Dilantin)
  • Streptokinase (Kabikinase, Streptase)
  • Tamoxifen (Nolvadex)
  • Ticlopidine (Ticlid)
  • Tinzaparin (Innohep); (Activase)
  • Tolbutamide (Orinase)
  • Torsemide (Demadex)
  • Urokinase (Abbokinase)
  • Warfarin (Coumadin)
  • Others

**** – November 2009 –  Two proton pump inhibitors Omeprazole and Esomeprazole were given a caution with use with Plavix

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