Polycystic Ovary SyndromeÂ (PCOS) is a common disorder related to an Endocrine Disorder.
It affects approximately 5-10% of women.
Often seen in women of reproductive age who are having abnormal or absent menstruation.
Is the leading cause of Infertility.
Other associated factors include Diabetes, obesity, and insulin resistance.
Abnormal LH (luteinizing hormone) levels relative to FSH (follicle-stimulating hormone) causes increased hormonal production by the theca cells of the Ovaries.
â€¢Â Â Â Â Facial hair (hirsutism) – 50% of cases
â€¢Â Â Â Â Abnormal or Absent menstruation – 50%
â€¢Â Â Â Â Obesity – 40%
â€¢Â Â Â Â Abnormal uterine bleeding – 30%
â€¢Â Â Â Â Development of male characteristics – 20%
â€¢Â Â Â Â Normal menstruation â€“ 20%
â€¢Â Â Â Â Insulin Resistance
â€¢Â Â Â Â Increased risk for type II diabetes
â€¢Â Â Â Â Depression
-Â Â Â Â Â Weight loss
IfÂ Pregnancy is desired some improvements have been seen with the following medications:
-Â Â Â Â Clomiphene
– Â Â Â Dexamethasone or other drugs for ovulatory stimulation
-Â Â Â Â Metformin
-Â Â Â Â Rosiglitazone
-Â Â Â Â Pioglitazone
IfÂ Pregnancy is not desired:
-Â Â Â Â Progesterone acetate
Management of excess hair:
-Â Â Â Â Dexamethasone
-Â Â Â Â Spironolactone
-Â Â Â Â Flutamide
– Â Â Â Finasteride
-Â Â Â Â Hysterectomy if severe symptoms are present.
-Â Â Â Â Followed by hormone replacement