It involves relationship between portal venous blood flow and the resistance offered to the blood flow within the liver.

Causes an increase in blood pressure in the portal system

Cirrhosis from alcohol or chronic viral hepatitis is most important cause of portal hypertension, although there are other causes.

Symptoms:

   -  Ascites
   -  Enlarged spleen
   -  Varices
   -  and others

Treatment:
  
   -  Propranolol
   -  Nadolol
   -  Isosorbide mononitrate
   -  Octreotide
   -  Terlipressin
   -  Transjugular intrahepatic portosystemic shunting
   -  Liver transplant