Primary Sclerosing Cholangitis is a chronic condition related to the Liver with Inflammation and scarring of the bile ducts.

This condition leads to Cirrhosis and Liver Failure

The specific cause of PSC is unknown but an autoimmune disorder is widely recognized.

There is an Association with Ulcerative Colitis

Seen in Men ages 20 – 50

  • 21 per 100,000 men
  • 6 per 100,000 women

There is a 10% risk of cholangiocarcinoma or liver cancer

  • 1-4% of those with Ulcerative Colitis develop PSC
  • But 70% of thoses with PSC also have ulcerative colitis

Diffuse inflammation of bilary tract — leads to fibrosis & stricture of bilary system



  • Jaundice
  • Itching
  • Fatigue
  • Fatty stools
  • Stool color change – Pale stools
  • Dark urine




Broad spectrum antibiotics



Liver Transplant

Survival – once onset of symptoms the average length of survival is 10 yrs

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