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Proton Pump Inhibitors is a group of drugs that affects and decreases the amount of acid in the Stomach. They are newer then the H2-Receptor Antagonists which can treat similar medical problems.

They are considered a very potent and effective way to manage stomach acid secretion.

Proton Pump Inhibitors are used quite often throughout the world and are some of the medication that are most purchased.

Typical Uses include:

–  Gastroesophageal Reflux Disease (Gerd)
–  Dyspepsia
–  Heartburn
–  Peptic Ulcers
–  Barrett’s esophagus
–  Zollinger-Ellison syndrome

Types/Common Names:

  –  Omeprazole   [Prilosec]
  –  Lansoprazole    [Prevacid]
  –  Esomeprazole    [Nexium]
  –  Pantoprazole    [Protonix]
  –  Rabeprazole    [Aciphex]
  –  Dexlansoprazole    [Kapidex]

Method of Action

–  Block a H+/K+ ATPase pump system also called the gastric proton pump
–  Occurs in the stomach at the perietal cell

Adverse Effects

–  Nausea
–  Vomiting
–  Headache
–  Fatigue
–  Rash
–  Itching
–  Abdominal pain
–  Erythema multiforme
–  Pancreatitis
–  Stevens Johnson Syndrome
–  others