This medication is used in the treatment for mental health, sleep, depression, and others. It’s patient expired in 2011.
Several generic versions: [Quepin, Syquel, and Ketipinor]
Method of Action
– This medication affects Dopamine, Serotonin, and Adrenergic Antagonsist receptors.
– It is a strong Antihistamine.
1.) Low doses – Acts as a histamine receptor blocker and is designed to help with sleep [Insomnia]
2.) Higher doses – Dopamine receptors are blocked
3.) Extended release – Takes longer period to be removed from system and dosing occurs in a longer time frame
4.) Extended release should only be used for adults – not given under age of 18.
– Initial Indictation/Approval was given by FDA in 1997
– May 2007 – Seroquel XR approved for acute treatment of schizophrenia
– Used in Adults
– Used in Children at least 13 years old
2.) Bipolar Disorder
– 2004 – Approved for treatment of Mania-Associated Bipolar Disorder
– October 2008 – Seroquel XR approved for Bipolar Disorder and Bipolar Mania
– Used for depressive episodes, mania episodes
– Used as Monotherapy
– Often used as Adjunct Therapy to Lithium, Valproate, or Lamotrigine
– Can be for Maintenance Treatment of Bipolar I Disorder in Adjunct with Lithium or Divalproex
– Used in Adults and Children (of at least 10 years of age)
– Used for Agitation largely among patients with Alzheimer’s disease
– Can worsen functioning in Elderly with Dementia – therefore should not be used.
– Used Adjunct for Depression – done so along with other medications.
Off label Uses
– Anger management
– Attention Deficit Hyperactivity Disorder
– Mood disorder
– Post-Traumatic Stress Disorder
– Tourette Syndrome
– Obsessive Compulsive Disorder
– Borderline Personality Disorder
– Sleepiness (somnolence)
– Upset Stomach
– Blurred Vision
– Increased Appetite
– Weight Gain
– Tardive Dyskinesia
– Often overdose symptoms are sedation, low blood pressure, and elevated heart rater.
– Some cases of cardiac arrhythmia, coma, and death have occurred due to overdose.
Recreational Use/Abuse Potential
– Abusive use is largely seen
– Appears to be caused by the sedative and calming down effects of the medication.
– Abuse occurs by oral route, IV routes, Intranasally/Snorting after being crushed, and other routes.
– Can be abused in combination with other medications or Drugs.
– When in Combination with Cocaine – often called Q-Ball
– A 2004 letter provided to The American Journal of Psychiatry from Los Angeles County Jail where more than 30% of inmates faked mental health illness in order to receive the medication.
– Link – Click Here
– When Abused can also be called: Quell, Snoozeberries, or Susie-Q
– A 2007 letter to editor of The American Journal of Psychiatry asked for additional studies to evaluate the addiction-potential of Quetiapine.
– Link – Click Here
– Authors of this letter work in the Ohio Correctional System.