Thrombolytic (Fibrinolytic) Drugs are a group of drugs also called tissue plasminogen activator (tPA) that are intended for use in patients with existing blood clots.
It is often used early in treatment of a Stroke
It is administered through an IV.
This medication should not be given to those who have the following:
1.) A current aneurysm
2.) A current brain tumor.
3.) Have had recent surgery
4.) Has a predisposition to bleeding
5.) Experienced a seizure when the stroke began
6.) Is having a current hemmorrhagic stroke
Method of Action:
- Enhances the breakdown of clots [fibrinolysis]
- Causes a conversion of plasminogen to plasmin
- Therefore this medication causes an over excited response
Typically prior to administraion of tPA a CT is done to ensure no current bleeding in the brain.
***Needs to be given within the first 3 hours of starting the ischemic stroke.
After 3 hours the damage done to the brain is difficult to reverse.
When this medication is given after 3 hours there has been no shown effective improvement.