tramadol50Tramadol is a medication that is used to treat pain.

It is used for moderate to severe pain.

This medication is also known as Ultram.

It is classified as a narcotic-like pain reliever.

It was first launched in 1977 in Germany.

It is not to be used in efforts to wean addicted patients from opiate drugs.

Not to be used to manage long-term opiate addiction.



  • Pain
  • Rheumatoid arthritis pain
  • Restless leg syndrome
  • Motor Neuron Disease
  • Fibromyalgia


Method of Action

  • Tramadol is similar to Levotphanol (Opioid medication) and Effexor.
  • Affects the Central Nervous System
  • Can be used in conjunction with Acetaminophen
  • Affects the M-opioid receptors (MOR)
  • Causes serotonin release
  • Prevents reuptake of Norephinephrine
  • Metabolized to O-Desmethyltramadol (O-DT) in the liver after consumed.


Side Effects

  • Nausea
  • Sweating
  • Constipation
  • Sweating
  • Seizures


Withdrawal Symptoms

  • Restless legs
  • Tremor
  • Thrashing in bed
  • Anxiety
  • Racing heart
  • Difficulty sleeping
  • Others


Psychological Dependence

Controversy is starting on the potential abuse of Tramadol.

Currently it is a Schedule 4 medication in Australia

Currently it is a Schedule 5 in states like  Arkansas, Tennessee, Illinois, New Mexico, New York, Ohio, West Virginia, Kentucky, Wyoming, Mississippi, North Dakota, Oklahoma and the U.S. military, with other states considering similar actions.

Prescribing information states that “psychological and physical dependence” can be seen.


Recreational Use

This type of use is seen in several instances.

In certain settings can be highly abused.


Veterinary Medicine

This medication can be used after injury or surgery for animals such as dogs, cats, rabbits and other small mammals.

It is one of the most useful medications to help treat animals in pain.

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