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Wegener’s Granulomatosis is a disease of unknown cause but is a form of Vasculitis.

Occurs when certain blood vessels that become inflamed and swollen.

Blood can become difficult to flow in several areas of the body.

Presents with Kidney problems and some vessel irritation or inflammation.

Affects Lungs, kidneys and other organs as well.

It is seen in both men and women of all ages, but far less often in younger patients.

Name after Dr. Friedrich Wegener

Symptoms

• Joint pain
• Fever
• Rash
• Chronic sinus pain
• Skin rash
• Weight loss

Classic findings are: sinuses, nose, ears, and trachea – the “windpipe”, the lungs, and the kidneys

But findings can almost be anywhere

Diagnosis

• Biopsy of affected area
• Examination under microscope will find the affected tissues.
• Blood work

Treatment

Acute phase

• Cyclophosphamide 3- 6 months

Once in remission

• Azathioprine
• Methotrexate
• Corticosteroids

For more serious cases the do not resolve with 1st line medication

• Rituximab
• Infliximab
• Etanercept
• And others